Endocrine Abstracts

Objective: Serum total sialic acid(SA) concentration is assessed as an up to date risk indicator of atherosclerosis and cardiovascular diseases.Methods: It was aimed to investigate about how SA levels are effected in overt or subclinical hypothyroidism (SH) and how it’s associated with other atherosclerosis risk factors because there is no study about these topics, though SA is intensively studied in recent years.Patients: Six...

Also cytopenies can be established in the evaluation of Graves’ disease (GD), isolated thrombocytopenia is very rare. Here, we present a case of immune thrombocytopenia incidentally found in the evaluation of GD. A 48-year-old female was admitted to our hospital with palpitation and anxiousness. The thyroid function tests were concordant with thyrotoxicosis. She had two subcentimetre nodules in the right thyroid lobe. Thyroid gland had increased iodine uptake. And thyroid...

Introduction: Infliximab is a tumour necrosis factor (TNF) α inhibitor and used for the treatment of psoriasis. Herein, we report a case of destructive thyroiditis accompanied by transient thyrotoxicosis resulting from the infliximab therapy for the treatment of psoriasis.Case report: A 57-year-old man suffered from psoriasis and was treated with infliximab therapy for 4 years. Thyroid function tests were normal before infliximab therapy. When the p...

Background: There are plenty of primary genetic or secondary causes for both hypercholesterolemia and hypertriglyceridemia. Two different genetic causes in one patient does not generally come to mind in first place.Aim: We report a case who has two genetic alterations as a cause of hypercholesterolemia and hypertriglyceridemia.Case report: 62 year-old male referred because of high serum lipid levels. He had no active complaint. The...

Insulin autoimmune syndrome (IAS) is a rare cause of hypoglycemia and characterized with autoantibodies to insulin in a patient without prior exposure to exogenous insulin. Medications with sulfydryl group and autoimmune diseases are known to be associated with this syndrome. Nearly 90% of the cases were reported in Japanese patients. We presented a Turkish patient with insülin autoimmune syndrome possibly caused by α-lipoic acid. A 62-year-old woman was admitted to ...

Introduction: Hypoglycemia is a complication of diabetes mellitus (DM) with high morbidity and mortality. Risk of hypoglycemia is affected by the type and duration of DM, use of insulin or oral antidiabetic agents, dietary habits and comorbidities. In this study, we aimed to understand frequency and causes of hypoglycemia in patients with type 2 DM in Turkish population and especially collect data about hypoglycemia in geriatric population.Methods: Betwe...

Context: The impact of abnormal cortisol secretion on cognitive functions in patients with mild autonomous cortisol secretion (MACS) remains uncertain.Objective: To assess cognitive functions, determine serum brain-derived neurotrophic factor (BDNF) concentration in patients with MACS, and investigate the possible association between cognitive subdomains and BDNF after minimizing the impact of body mass index (BMI) and visceral adiposity.<p class="ab...

Objective: In differentiated thyroid carcinoma (DTC), TSH suppression with levothyroxine (L-T4) is a standard treatment for reducing tumor recurrence after total thyroidectomy. This study aims to evaluate the effect of long-term TSH suppression on the development of sarcopenia and frailty in elderly patients with DTC.Method: Seventy patients aged 60 years and older with stable TSH levels during the last year and under L-T4 due to DTC were included in the...

Dipeptidyl peptidase 4 (DPP-4) is thought to play a role in the pathophysiology of metabolic and inflammatory diseases. Increased ADA activity has been suggested to induce insulin resistance and inflammation. We investigated DPP-4 and ADA activities, serum nitric oxide (NO) level and nitric oxide synthase (NOS) activity which are the oxidative stress parameters in patients with PCOS. Fifty two women with PCOS and 41 healthy women were included in this study. Serum ADA activity...

Objective: Thyroid incidentaloma is a common endocrinological disorder. Current literature regarding the risk of thyroid cancer in incidentalomas found in patients with non-thyroid cancer is limited. The aim of the present study was to investigate the frequency of thyroid malignancy in thyroid incidentalomas detected in patients with non-thyroid cancer.Methods: The database of 287 thyroid nodules from 161 patients with a history of non-thyroid cancer fol...